John Kurhanewicz Selected Research

Pyruvic Acid (Pyruvate)

1/2022	Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Immune Checkpoint Inhibitor Therapy in Prostate Cancer.
1/2022	Clinical translation of hyperpolarized 13 C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging.
11/2021	Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13 C MR EPSI studies of liver tumors.
2/2021	Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models.
1/2021	Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models.
12/2020	Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI.
1/2020	Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model.
10/2019	Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer.
10/2019	Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion.
2/2019	The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI.

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John Kurhanewicz Research Topics

Disease

82	Neoplasms (Cancer) 01/2022 - 10/2002
78	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 10/2002
10	Adenocarcinoma 02/2021 - 10/2008
6	Neoplasm Metastasis (Metastasis) 01/2020 - 04/2008
4	Renal Cell Carcinoma (Grawitz Tumor) 09/2018 - 01/2013
3	Carcinogenesis 11/2017 - 01/2013
2	Lymphoma (Lymphomas) 10/2021 - 10/2018
2	Brain Neoplasms (Brain Tumor) 01/2019 - 02/2010
2	Breast Neoplasms (Breast Cancer) 11/2017 - 02/2010
2	Reperfusion Injury 10/2017 - 11/2011
2	Hypoxia (Hypoxemia) 01/2017 - 02/2010
2	Glioma (Gliomas) 01/2017 - 02/2010
2	Disease Progression 04/2012 - 01/2010
2	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 10/2011 - 01/2007
2	Necrosis 07/2010 - 03/2010
2	Glioblastoma (Glioblastoma Multiforme) 02/2010 - 02/2010
2	Extranodal Extension 04/2008 - 04/2008
2	Intervertebral Disc Degeneration 02/2008 - 12/2005
2	Atrophy 02/2007 - 07/2004
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 10/2018
1	Insulin Resistance 01/2018
1	Diabetes Mellitus 01/2018
1	Bone Fractures (Bone Fracture) 12/2017
1	Dehydration (Water Stress) 08/2015

Drug/Important Bio-Agent (IBA)

41	Lactic Acid (Lactate)FDA LinkGeneric 11/2021 - 06/2006
36	Pyruvic Acid (Pyruvate)IBA 01/2022 - 10/2008
16	Biomarkers (Surrogate Marker)IBA 10/2021 - 12/2005
13	Choline (Choline Chloride)IBA 01/2017 - 10/2002
11	Prostate-Specific Antigen (Semenogelase)IBA 02/2017 - 01/2004
10	Citric Acid (Citrate)FDA LinkGeneric 12/2011 - 11/2003
7	Urea (Carbamide)FDA LinkGeneric 01/2022 - 07/2010
7	Alanine (L-Alanine)FDA Link 01/2020 - 06/2006
6	PolyaminesIBA 10/2011 - 10/2002
5	AndrogensIBA 02/2021 - 04/2003
5	Carbon-13IBA 01/2019 - 02/2010
5	Protons (Proton)IBA 09/2017 - 12/2004
4	Biological ProductsIBA 02/2020 - 01/2013
4	Messenger RNA (mRNA)IBA 10/2019 - 02/2010
4	CreatineIBA 12/2017 - 12/2004
4	CarbonIBA 02/2010 - 09/2007
3	Glutathione (Reduced Glutathione)IBA 02/2021 - 06/2013
3	EnzymesIBA 01/2020 - 08/2015
3	Glutamic Acid (Glutamate)FDA Link 01/2019 - 11/2009
3	Phosphorylcholine (Phosphocholine)IBA 07/2008 - 11/2003
2	gamma-Aminobutyric Acid (GABA)IBA 10/2021 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 02/2021 - 06/2013
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2020 - 10/2015
2	Bicarbonates (Hydrogen Carbonate)IBA 10/2019 - 07/2010
2	Indicators and Reagents (Reagents)IBA 10/2019 - 04/2019
2	Lactate Dehydrogenase 5IBA 02/2019 - 09/2018
2	Pharmaceutical PreparationsIBA 10/2018 - 04/2018
2	Capsules (Microcapsules)IBA 04/2018 - 02/2014
2	Sodium Bicarbonate (Baking Soda)FDA LinkGeneric 01/2016 - 07/2010
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 06/2013 - 11/2011
2	CollagenIBA 04/2012 - 02/2008
2	Proteins (Proteins, Gene)FDA Link 02/2010 - 04/2003
2	Hormones (Hormone)IBA 02/2007 - 12/2004
1	Immune Checkpoint InhibitorsIBA 01/2022
1	Neurotransmitter Agents (Neurotransmitter)IBA 10/2021
1	Tricarboxylic AcidsIBA 02/2021
1	Glutamine (L-Glutamine)FDA Link 02/2021
1	taxaneIBA 01/2020
1	IsotopesIBA 01/2020
1	PlatinumIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	IronIBA 04/2019
1	RadiopharmaceuticalsIBA 01/2019
1	AntigensIBA 01/2019
1	phosphoramidic acidIBA 01/2019
1	Rituximab (Mabthera)FDA Link 10/2018
1	Lenalidomide (CC 5013)FDA Link 10/2018
1	Dihydrotachysterol (AT 10)IBA 10/2018
1	DioxygenasesIBA 10/2018
1	Methotrexate (Mexate)FDA LinkGeneric 10/2018
1	Mifepristone (RU 486)FDA Link 04/2018
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 04/2018
1	Insulin (Novolin)FDA Link 01/2018
1	Streptozocin (Streptozotocin)FDA Link 01/2018
1	Oxidoreductases (Dehydrogenase)IBA 10/2017
1	fluorocholineIBA 02/2017
1	FluorineIBA 02/2017
1	alpha-hydroxyglutarateIBA 01/2017
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017
1	AcidsIBA 01/2016
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2016
1	AminesIBA 01/2016
1	Nicotinamide PhosphoribosyltransferaseIBA 10/2015
1	Niacinamide (Nicotinamide)FDA LinkGeneric 10/2015
1	NAD (NADH)IBA 10/2015

Therapy/Procedure

26	Therapeutics 01/2022 - 10/2002
18	Radiotherapy 01/2021 - 11/2004
14	Prostatectomy (Retropubic Prostatectomy) 01/2022 - 10/2002
7	Brachytherapy 11/2013 - 01/2004
6	Bioreactors (Bioreactor) 03/2016 - 02/2010
4	Drug Therapy (Chemotherapy) 07/2021 - 12/2004
3	Castration 02/2021 - 01/2019
2	Aftercare (After-Treatment) 02/2010 - 05/2006
1	Biological Therapy 10/2018
1	Operative Surgical Procedures 12/2017
1	Arthroplasty 12/2017